profound existential dread
definitions
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An intense, overwhelming feeling of anxiety or fear concerning the fundamental nature of existence, the meaning of life, or the inevitability of death.zh: 深层的存在主义恐惧
examples
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Staring at the vast, empty cosmos, he was overcome by a sense of profound existential dread.
凝视着浩瀚而空旷的宇宙,他被一种深层的存在主义恐惧所淹没。