main cause
definitions
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The primary reason, factor, or agent responsible for a particular result, effect, or situation.zh: 主要原因
examples
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Lack of sleep was the main cause of his fatigue.
睡眠不足是他疲劳的主要原因。
Lack of sleep was the main cause of his fatigue.
睡眠不足是他疲劳的主要原因。