ultimate tragedy
definitions
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The most extreme, profound, or severe instance of a tragic event, often involving irreparable loss or immense suffering.ru: Величайшая трагедия
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A final, conclusive, or terminal disaster that serves as the end point of a series of unfortunate events.ru: Окончательная трагедия
examples
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The loss of all his family members was the ultimate tragedy of his life.
Потеря всей его семьи стала величайшей трагедией в его жизни.
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In the play, the protagonist's death serves as the ultimate tragedy.
В пьесе смерть главного героя служит окончательной трагедией.