deep sin
definitions
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A moral transgression or wrongdoing that is considered extremely grave, profound, or spiritually damaging.ru: Тяжкий грех
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A sin that is deeply ingrained, habitual, or carries a heavy psychological burden of guilt.ru: Глубоко укоренившийся грех
examples
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He believed that his deep sin would prevent him from finding peace.
Он верил, что его тяжкий грех не даст ему обрести покой.
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The artist struggled with the deep sin of his past actions throughout his life.
Художник всю жизнь боролся с глубоким грехом своих прошлых поступков.