lose hope
definitions
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to stop feeling optimistic or believing that something will happenja: 希望を失う
examples
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Despite the setbacks, he refused to lose hope.
挫折にもかかわらず、彼は希望を失うことを拒んだ。
Despite the setbacks, he refused to lose hope.
挫折にもかかわらず、彼は希望を失うことを拒んだ。