potential irreversible harm
definitions
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The possibility of causing damage, injury, or negative effects that cannot be undone, repaired, or reversed once they have occurred.fr: Dommage irréversible potentiel
examples
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The new chemical plant was denied a permit due to the potential irreversible harm it could cause to the local ecosystem.
L'autorisation de la nouvelle usine chimique a été refusée en raison du dommage irréversible potentiel qu'elle pourrait causer à l'écosystème local.