great sin
definitions
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A serious violation of moral, ethical, or religious laws; a grave wrongdoing that offends a deity or a community's conscience.fr: grand péché
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A major mistake, error in judgment, or a significant social or practical blunder.fr: grande erreur
examples
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You have committed a great sin by flooding the temple and harming the innocent.
Vous avez commis un grand péché en inondant le temple et en blessant les innocents.
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To ignore the warnings was a great sin against common sense.
Ignorer les avertissements était une grande erreur contre le bon sens.