great concern
definitions
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A state of intense worry, anxiety, or apprehension regarding a specific situation, event, or person.fr: Grande inquiétude
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A matter of significant importance or something that requires serious attention and consideration.fr: Grande importance
examples
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The heavens watched this decline with great concern.
Les cieux observaient ce déclin avec une grande inquiétude.
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The safety of the passengers is a matter of great concern to the airline.
La sécurité des passagers est une question de grande importance pour la compagnie aérienne.