fundamental mysteries
definitions
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Essential or foundational questions, phenomena, or truths that are difficult to understand or explain, often relating to existence, the universe, or human nature.fr: Mystères fondamentaux
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Deep-seated or underlying enigmas that form the very essence or basis of a subject, existence, or complex situation.fr: Énigmes profondes
examples
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Scientists are still trying to solve the fundamental mysteries of the universe.
Les scientifiques tentent toujours de résoudre les mystères fondamentaux de l'univers.
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The book explores the fundamental mysteries of human consciousness.
Le livre explore les énigmes profondes de la conscience humaine.