existential anguish
definitions
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A profound feeling of dread, anxiety, or suffering stemming from the realization of the inherent meaninglessness of life, the inevitability of death, or the overwhelming burden of individual freedom and responsibility.fr: Angoisse existentielle
examples
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After staring at the vast, empty night sky, he was overcome by a sense of existential anguish.
Après avoir contemplé le vaste et vide ciel nocturne, il fut envahi par un sentiment d'angoisse existentielle.