ultimate tragedy
definitions
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The most extreme, profound, or severe instance of a tragic event, often involving irreparable loss or immense suffering.de: Größte Tragödie
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A final, conclusive, or terminal disaster that serves as the end point of a series of unfortunate events.de: Endgültige Katastrophe
examples
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The loss of all his family members was the ultimate tragedy of his life.
Der Verlust seiner gesamten Familie war die größte Tragödie seines Lebens.
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In the play, the protagonist's death serves as the ultimate tragedy.
Im Stück dient der Tod des Protagonisten als die endgültige Tragödie.