potential irreversible harm
definitions
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The possibility of causing damage, injury, or negative effects that cannot be undone, repaired, or reversed once they have occurred.de: Möglicher irreversibler Schaden
examples
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The new chemical plant was denied a permit due to the potential irreversible harm it could cause to the local ecosystem.
Die neue Chemiefabrik erhielt aufgrund der potenziellen irreversiblen Schäden für das lokale Ökosystem keine Genehmigung.