fundamental problem
definitions
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A basic, central, or essential issue that lies at the root of a situation, system, or conflict.de: Grundproblem
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A deep-seated difficulty or contradiction within the theoretical, logical, or scientific basis of a field of study.de: Grundsatzproblem
examples
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The lack of funding is the fundamental problem facing the project.
Der Mangel an Finanzierung ist das grundlegende Problem des Projekts.
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Quantum mechanics presents a fundamental problem for classical physics.
Die Quantenmechanik stellt ein Grundsatzproblem für die klassische Physik dar.